Gabriella Wan

  • Welcome to the FLF community! We look forward to deepening our engagement with you.

    Remember to be on the lookout for an email from us where there will be a link to schedule a time to meet with the NSF leadership team to discuss the specifics of your involvement with the Fund.

    Lastly, you can click on the tabs above based on your background for more information about how to jumpstart your involvement with FLF and the NSF. We are so happy to have you!


  • signed up on Schedule a Meeting to Learn About NSF 2021-11-11 15:03:45 -0700

    Schedule a Meeting to Learn About NSF

    Get involved! — Intersect Lab

    Thank you for your interest in learning more about NSF! We are eager to meet you and to discuss how you might best contribute to our efforts to combat NAFLD and NASH. Please enter your contact information below and select the category that best describes your background.

    When you submit this form, you will get email from [email protected] In this email you will be asked to activate your account if you have not already done so. Additionally, there will be a link to schedule a time to meet with the NSF leadership team to discuss the specifics of your involvement with the Fund. This meeting is not required, but we would love to speak with you if you have the time.

    Sign up

  • Fatty Liver Foundation to Amplify the Voices of People with NAFLD/NASH and Highlight New NAFLD/NASH Screening Initiatives While Attending The Liver Meeting® 2021

    FOR IMMEDIATE RELEASE

    Thursday, November 11, 2021, Boise, IDAHO The Fatty Liver Foundation (FLF) today announced its activities while attending the 72nd American Association for the Study of Liver Diseases (AASLD) Annual Meeting, taking place from November 12 to 15, 2021. 

    Read more

  • Medical Providers

    Thanks for signing up to get involved with NSF! As a medical provider, you have the opportunity to play a significant role in our screening efforts.

    Learn About Non-Invasive Screening Methods

    Regardless of whether you are a primary care provider or a specialist, you can help us work towards a world less impacted by NAFLD/NASH by adopting non-invasive screening methods in your practice. You may know of some of these non-invasive testing methods already, but click on each below if you would like to learn more:

    Blood-Based Tests

    Imaging Tests

     

    Update Your Clinical Care Pathway for NAFLD/NASH

    Another way to get involved with the NSF is to consider adopting an updated clinical care pathway, such as the one below from this recent article.

    Though the AASLD has not yet changed their guidelines to recommend screening in asymptomatic populations, doctors and advocacy groups have been working tirelessly towards an update. The importance of screening asymptomatic individuals cannot continue to be underemphasized when the majority of patients do not have symptoms until they reach end-stage disease! Join us and many others in being proactive in screening for NAFLD/NASH, and help your patients address their disease before it progresses further.

     

    Stay Connected for Future Grant Funding Opportunities

    As we grow the NSF, there will likely be opportunities to apply for grant funding to support adoption of non-invasive screening in your practice. If you would like to be alerted when grant opportunities become available, please email [email protected] with the subject line "Future Grant Opportunities," with your full name, your practice name and location, and the number of patients you expect to be able to screen per month. We look forward to working with you to bring non-invasive screening and proactive clinical care pathways to all Americans!


  • Industry Representatives

    Thanks for signing up to get involved with NSF! As an industry representative, you have the opportunity to play a significant role in and benefit greatly from our screening efforts.

    Join the Partnership

    As a public-private partnership, the NSF is an opportunity for your company to get involved in raising public awareness of NAFLD/NASH, increase the patient pool available for clinical trials, and generate data about long-term patient outcomes to improve the drug approval process. By joining, you will become a part of a coalition fighting for better access to care for NAFLD/NASH patients.

    There are already several partners and supporters of the NSF, highlighted on our website here. If you are ready to become a partner and make a contribution, you can do so today on our website. If you are interested in becoming a supporter of the Fund, please mention this in our meeting and we can discuss your timeline for eventual contribution.

     

     


  • published Patients in Thank you for your interest in the NSF! 2021-11-10 13:55:00 -0700

    Patients

    Thanks for signing up to get involved with NSF! As a patient, you play a critical role in all of FLF's efforts. You are the reason we exist and your participation is of the utmost importance for the success of our programs.

    Spread the Word about the NSF

    We need your help to amplify our message for the NSF! Share our efforts with your family, friends, coworkers, mailman and anyone else you can chat up for a few minutes. Download our NSF Fact Sheet for a short summary of what the Fund aims to achieve and follow us on Twitter @FLF_NSF to stay updated on the latest news regarding the Fund.

     

    Join the Wellness League

    The Wellness League is FLF's digital platform to help empower people to take charge and manage their lives with regards to routine, diet, exercise, and medication as they fit into their social and occupational activities. The Wellness League platform will help participants track their key metrics (BMI, bloodwork, scans), encourage reduction of risk classification through lifestyle and diet changes, connect to local resources, and learn more about and connect to clinical trial opportunities. The content and frequency of communication on the Wellness League platform will be fully customizable, dependent on both an individual’s disease stage and preferences. Though it is a digital platform, participants in the Wellness League will be supported by real people called Wellness Navigators; some will be embedded in local communities through SUNN-2 and some will be entirely virtual. To the extent possible, Wellness Navigators will be patients themselves, able to draw on their personal experience and understanding. To learn more about the Wellness League, view and download the flyer here.

    Though the official Wellness League platform is scheduled to go live in January 2022, you can opt to join the cause now. To enroll in the Wellness League, please fill out this consent form and schedule a meeting to speak with a Wellness Navigator

     

    FLF Needs Your Support Now!

    FLF could not operate without the support of our community. Through donations big and small, we are able to keep our screening programs and patient support initiatives running and expand the services we can offer. To help us keep making progress in the fight against NAFLD/NASH, we need your contribution today!

     


  • published Learn About FLF in ABOUT 2021-11-09 14:46:59 -0700

    Learn About FLF

    About the Fatty Liver Foundation (FLF)

    The Fatty Liver Foundation is the only national, non-profit patient advocacy organization dedicated to improving the identification, diagnosis, treatment, and support of Americans with fatty liver, NAFLD or NASH through awareness, screening, education and patient outreach. FLF’s goal is to improve the lives of both asymptomatic and diagnosed patients by raising awareness among the general public and medical communities, promoting non-invasive screening methodologies, educating patients, and championing the development of responsive lifestyle support systems for individuals of the growing epidemic of fatty liver disease. FLF was founded in 2017 by NASH patient Wayne Eskridge and his wife and caregiver Rosemary Wickowski, pictured below.

    You can read more about Wayne's story here. He remains actively involved in the Foundation, and you can read about the rest of the management team here. For a concise and sharable document about the Foundation, you can download a fact sheet about us here.

    Summary of Links:

     

    FLF's Key Programs

    The NAFLD Screening Fund (NSF)

    The NSF is a public-private partnership led by FLF with the goal of generating funding for NAFLD/NASH screening. FLF has started to bring together a multitude of stakeholders, including industry representatives, clinical research organizations, communications companies, other non-profit organizations, and, of course, patients. By creating a pool of resources to encourage preventive screening activities, all stakeholders stand to benefit. Screening more people for NAFLD/NASH is a critical and achievable goal that will help shape the way society engages with our growing burden of noncommunicable diseases. Beyond increasing preventive screening, secondary goals of the NSF include increasing awareness of the silent epidemic, establishing a bigger population for clinical trial recruitment, creation of a safety net ecosystem for ongoing support and care for afflicted individuals. You can download a fact sheet about the NSF here and click here to read more about the initiative.

    Summary of Links:

     

    Screening for Undiagnosed NAFLD/NASH (SUNN) Studies

         

    One of the main objectives of FLF is to promote screening in asymptomatic individuals. The Foundation has made progress toward this goal through research initiatives called the SUNN studies. SUNN-1 was implemented in Galveston County, TX and successfully screened over 1000 individuals using a FibroScan machine at community locations. The report from SUNN-1 is being published in PLOSOne. You can learn more about the SUNN Studies here and download the SUNN-1 manuscript here. FLF is in the planning and fundraising phase for SUNN-2, which will expand on the tactics and findings of SUNN-1 to screen more people while also connecting them to care and providing support. SUNN-2 will initially return to the Galveston County, TX area covered in SUNN-1, with expansion sites in Waco, TX and the Washington, DC/Maryland/Virginia area. If you are interested in supporting SUNN-2, please consider making a donation to the NSF.

    Summary of Links

     

    The Wellness League

    The Wellness League is FLF's digital platform to help empower NAFLD/NASH patients to take charge and manage their lives with regards to routine, diet, exercise, and medication as they fit into their social and occupational activities. The Wellness League platform is scheduled to go live in January 2022 and will help participants track their key metrics (BMI, bloodwork, scans), encourage reduction of risk classification through lifestyle and diet changes, connect to local resources, and learn more about and connect to clinical trial opportunities. The content and frequency of communication on the Wellness League platform will be fully customizable, dependent on both an individual’s disease stage and preferences. Though it is a digital platform, participants in the Wellness League will be supported by real people called Wellness Navigators; some will be embedded in local communities through SUNN-2 and some will be entirely virtual. Wellness Navigators will have strong linkages to the communities from which they come. To learn more about the Wellness League, view and download the flyer here.

    Summary of Links

     

    The Liver Friendly Diet

    As the only available treatment for NAFLD/NASH currently available is diet and lifestyle change, FLF has designed and promoted the Liver Friendly Diet, accessible here in its entirety. NAFLD/NASH patients are often told by their doctors to lose weight and come back in a few months. Though this seems like straightforward advice, people need more hands on and specific support to be successful in changing their habits. FLF promotes the Liver Friendly Diet as one aspect of the lifestyle change equation, while also encouraging patients to understand that they are really changing their lives forever, not just adopting a temporary diet. The Liver Friendly diet is similar to a Mediterranean diet with some liver-specific recommendations for foods such as extra virgin olive oil and coffee. Click here for a one-page printout of the Liver Friendly diet (great for sticking on your fridge!) and a short fact sheet on how you can get started on loving your liver today.

    Summary of Links:

     

    FLF Needs Your Support Now!

    FLF could not operate without the support of our community. Through donations big and small, we are able to keep our screening programs and patient support initiatives running and expand the services we can offer. To help us keep making progress in the fight against NAFLD/NASH, we need your contribution today!


  • Partners and Supporters

    The NAFLD Screening Fund is a collaborative effort led by FLF. Our partners and supporters will continue to grow as the Fund expands.

     

    Our partners, those who support the Fund, are:

    Ms. Athena Pei Tung

    Madrigal Pharmaceuticals

     

     Terns Pharmaceuticals

     

    Our supporters, those who have expressed interest in becoming a partner of the Fund, are:

     

     

     

     

     

    H.C. Wainwright & Co., LLC « ARM's 7th Annual Cell & Gene Therapy Investor  Day « The Alliance for Regenerative Medicine Access 

     

     


  • published NAFLD Screening Fund Overview 2021-09-26 11:40:29 -0600

    NAFLD Screening Fund Overview

    WHAT'S THE PROBLEM?

     

     

     

     

     

     

     

     

    100 million people have NAFLD and don't know it

    20 million people have NASH and don't know it

    5 million people have cirrhosis and don't know it

    • A tsunami of disease is building in society and being exacerbated by the current COVID-19 pandemic
    • Most people have no knowledge of NASH and doctors rarely warn patients of risk or attempt diagnosis absent symptoms
    • There are no treatments and not enough patients to fill clinical trials necessary for approval

     

    THE SOLUTION

    Public-Private Partnerships (PPP) 101 | by Faiaz | The Curious Commentator  | Medium

     

     

     

     

     

     

     

    Mobilize a public-private partnership

    • Supporting broad outreach through patient advocates
    • Mobilizing local community peer-to-peer groups
    • Increasing uptake of preventive screening practices

     

    THE PAYOFF 

    Plan Participant Data Ownership Creates Concerns.

     

     

     

     

     

     

     

     

    Healthier, smarter patients, better care, reduced cost, improved participant pool

    • Saving lives through continued education & monitoring
    • Encouraging participation via robust clinical trial support
    • Improving collaboration instead of stifling competition

     

    With recent advancements in the diagnostics and potential treatments for NAFLD, screening and testing are now the critical nexus between identification of disease and effective intervention. To meet this need, the NAFLD Screening Fund’s primary objective is to scale-up evidence-based screening and testing for NAFLD. Funded activities would boost the screening practices needed to identify asymptomatic disease and staging of NAFLD/NASH patients.

    The expansion of screening and staging of fatty liver disease is a model of community outreach that has been proven by FLF in medical and non-medical settings. The Fund’s impact will be expanded education and awareness of NAFLD, achieved through screening, which has been shown to empower individuals’ ownership and participation in their health and healthcare. Through multiple site collaborations, new screening technologies, improved data management systems, and more trained personnel, the Fund will be leveraged to rapidly scale up community screening efforts. The NAFLD Screening fund will be the catalyst for greater patient engagement in research and development, including treatment preparedness as new therapies become available. It is a mechanism through which many streams of financial support, both public and private, can be coordinated and focused on this rapidly growing health threat.


  • published Learn More in NAFLD Screening Fund Overview 2021-09-24 11:51:09 -0600

    Learn More

    Thank you for your interest in the NAFLD Screening Fund!

    We are looking for both partners and supporters for the Fund. If you would like to learn more about what being a partner or supporter entails or have any other questions, please email us at [email protected]. We are happy to communicate over email or to set up a time to connect over Zoom. Please let us know your preference and we will get back to you as soon as possible. 

    Fatty Liver Foundation Launches a Public-Private Partnership to Combat the Silent Epidemic of Nonalcoholic Fatty Liver Disease (N)

    Liver disease is an ignored epidemic. FLF intends to change the paradigm with the NAFLD Screening Fund.

     Building on the experience of FLF, the leading patient advocacy organization, the NAFLD Screening Fund aims to identify and support at-risk populations to combat the rising incidence and mortality of NAFLD in the United States.

    The Fatty Liver Foundation (FLF) is launching the NAFLD Screening Fund, a new five-year, multi-stakeholder, public-private partnership aimed at accelerating progress in the detection, diagnosis, staging, care, and research of non-alcoholic fatty liver disease (NAFLD) among at-risk and asymptomatic populations in the United States, where there is a significant unmet need.

    Despite advances in research, diagnosis, and care, NAFLD places a heavy burden on individuals, families, and health care systems. Before COVID-19, it was estimated that more than 100 million Americans had NAFLD or its more advanced and aggressive form, non-alcoholic steatohepatitis (NASH), and most were unaware of it. Since the onset of COVID-19, the average American has gained 29 pounds, contributing to the growing burden of noncommunicable lifestyle diseases such as obesity and diabetes, and greatly increasing the at-risk population who remain undiagnosed for NAFLD. The societal tragedy is that if diagnosed and addressed early enough, NAFLD can be reversed.

    The level of screening for NAFLD among high-risk and asymptomatic populations remains woefully inadequate in medical and community-based settings and this lack of services has only been exacerbated by COVID-19. People with NAFLD and metabolic syndrome are four times more likely to develop severe manifestations of COVID-19 than those without NAFLD, regardless of the presence of diabetes. With COVID-19 disproportionately impacting people at-risk for and living with NAFLD by threatening their timely diagnosis and care, and increasing their risk of severe disease, it is more urgent than ever to address these health disparities. Though these same issues exist nationwide, they are particularly acute in under served and non-white communities.

    “Our commitment to re-imagining NAFLD screening goes beyond FLF’s SUNN-1 (Screening for Undiagnosed NAFLD and NASH) study, to helping close the gaps in prevention and linkage to care and/or clinical trials for at-risk, asymptomatic populations through innovative screening models in underserved communities,” said Wayne Eskridge, CEO and Co-Founder of FLF. “We must work with other organizations and stakeholders in order to successfully raise awareness, address health disparities, and increase access to screening. We are at a tipping point where we can help catalyze and change the course of NAFLD diagnosis and care for all Americans.”

    “The number of NAFLD cases is rising rapidly among the U.S. adult population (aged ≥15 years), and prior to COVID-19 was projected to reach 33.5% in 2030. We don’t yet know how extensive the long-term damage of the pandemic will be for chronic disease patients, but we can expect that it will likely catalyze more serious problems. Unfortunately, we are already making most diagnoses late in the course of disease, leading to potentially serious complications and outcomes,” says Neeraj Mistry, MD, MPH, Chief Medical Officer of FLF. “The NAFLD Screening Fund is part of FLF’s broader commitment to mobilize new resources and strengthen the capacity of key NAFLD stakeholders to reverse these trends. This new initiative not only promises to prevent thousands of premature deaths, but also to contribute to greater equity in NAFLD care and research.”

    FLF’s NAFLD Screening Fund is a public-private partnership to mobilize leading organizations from the private sector, philanthropic foundations, public health agencies, and non-profit organizations. The Fund is supported by leading companies and individuals from the private and philanthropic sectors including Applied Clinical Education, CME Zone, Gastroenterology & Endoscopy News, Madrigal Pharmaceuticals, Inc., McMahon Group, and Terns Pharmaceuticals, Inc., and Ms. Athena Pei Tung.

    The NAFLD Screening Fund aims to achieve the following outcomes by 2026:

    1. Fund community-based screening projects for NAFLD/NASH in undiagnosed, asymptomatic at-risk populations.
    2. Drive awareness of NAFLD and the importance of early detection.
    3. Foster education about healthy lifestyles.
    4. Support NAFLD and NASH patients with linkage to care and clinical trial enrollment education.
    5. Strengthen networks and collaborations for NAFLD/NASH screening at local, regional, and national levels.
    6. Unite the voice of the NAFLD/NASH community, including patient organizations and groups, to advocate for more effective NAFLD/NASH screening, staging and care.
    7. Provide data to guide research and regulatory decision making where patient interests are impacted.

    “Key to reversing the rise in NAFLD cases and mortality rates is our ability to work together to leverage and expand the will and resources that currently exist, supporting the creation of a common agenda to maximize impact through collective action,” says Henry E. Chang, Executive Director of FLF. “In practical terms, with the necessary funding and expertise, the NAFLD Screening Fund has the potential to support 50,000 NAFLD patients, fund various scalable and sustainable NAFLD screenings and linkage to care projects that are designed to address health disparities among at-risk and under served populations, and help accelerate the development of drug regimens for the treatment of NAFLD and NASH.”

    Learn how you can help support the NAFLD Screening Fund and address this significant unmet need by signing up here.

    About the Fatty Liver Foundation

    The Fatty Liver Foundation is a non-profit patient organization dedicated to improving the identification, diagnosis, treatment and support of people living with fatty liver, NAFLD or NASH through awareness, screening, education, and patient outreach. FLF’s goal is to improve the lives of both asymptomatic and diagnosed patients by raising awareness, advancing wellness screening, educating patients, and championing the development of responsive support systems for individuals of the growing epidemic of fatty liver disease. Connect with us on www.fattyliverfoundation.org, Facebook (Fatty Liver Foundation JUST LIVER NEWS), Twitter (@LiverSaver), and YouTube (Fatty Liver Foundation). 

    About the NAFLD Screening Fund

    With recent advancements in the diagnostics and potential treatments for NAFLD, screening and testing are now the critical nexus between identification of disease and effective intervention. To meet this need, the NAFLD Screening Fund’s primary objective is to scale-up evidence-based screening and testing for NAFLD. Funded activities will boost the screening practices needed to identify asymptomatic disease and staging of NAFLD/NASH patients.

    The expansion of screening and staging of fatty liver disease is a model of community outreach that has been proven by FLF in medical and non-medical settings. The Fund’s impact will be expanded education and awareness of NAFLD, achieved through screening, which has been shown to empower individuals’ ownership and participation in their health and healthcare. Through multiple site collaborations, new screening technologies,  improved data management systems, and more trained personnel, the Fund  will be leveraged to rapidly scale up community screening efforts. The NAFLD Screening Fund will be the catalyst for greater patient engagement in research and development, including treatment preparedness as new therapies become available. It is a mechanism through which many streams of financial support, both public and private, can be coordinated and focused on this rapidly growing health threat.

    partners-banner.png

     

     

     

     


  • published NSF Fact Sheet in NAFLD Screening Fund Overview 2021-09-15 13:15:03 -0600

    NSF Fact Sheet

    SCOPE OF PROBLEM

    A tsunami of liver disease is building in society:

    • 100 million Americans have nonalcoholic fatty liver disease and don’t know it
    • 5 million have cirrhosis and don’t know it
    • Wellness screening for asymptomatic disease is not commonly done in the US

    The problem has been exacerbated by the COVID-19 pandemic:

    • The average American has gained 29 pounds during the pandemic
    • This extra weight greatly increases risk of disease and death

    NAFLD and NASH are unknown to most people:

    • Most people have no knowledge of liver disease, other than alcohol-related liver disease which carries tremendous stigma
    • Doctors rarely warn patients of risk or attempt to diagnose absent symptoms

    There are no treatments for NASH:

    • There are not enough patients to fill clinical trials necessary for drug approval 
    • Medical providers and industry groups are not working collaboratively to address their common issue

    DESCRIPTION OF SOLUTION

    We must change the paradigm of blindness regarding liver disease from the grassroots, at a family and community level.


    The NAFLD Screening Fund is a public-private partnership led by FLF: 

    • To fund screening for NAFLD/NASH in undiagnosed, asymptomatic populations 
    • To drive awareness and early detection of risk
    • To foster education about healthy lifestyles 
    • To support patients identified with disease with linkage to care and education about enrollment in clinical trials

    COST

    $5 million for the first 2 years of operation

    OBJECTIVES

    Provide financing to advance the deployment of community-based, NAFLD/NASH screening models and other interventions.


    Accelerate the development of NAFLD/NASH treatments by expanding the patient pool available for clinical trials.


    Sensitize and activate treatment preparedness within the patient and payor communities and enroll screened individuals into FLF’s safety net Wellness League for continued support.

    OVERSIGHT

    Governance Board


    Scientific Advisory Committee


    Grant Application Process


  • published Right Upper Quadrant (RUQ) Pain in SCIENCE 2021-07-21 12:04:19 -0600

    Right Upper Quadrant (RUQ) Pain

    Many patients in our forums report experiencing right upper quadrant (RUQ) pain. Though NAFLD and NASH are largely asymptomatic, RUQ pain occurs in about one-third of NAFLD/NASH patients and varies in character and severity; some people report a mild aching fullness sensation, while others experience steady sharp pains that can disrupt their sleep.[i] Unfortunately, when patients report RUQ to their primary care providers, routine testing such as bloodwork or an ultrasound may not show anything wrong. With no physical indication that something is wrong or anything identifiable as the issue, pain may go unaddressed for years. If it is addressed, it isn’t uncommon for patients to be referred to psychiatric care, as if the RUQ pain were a symptom of a mental disorder as opposed to a physical disorder like NAFLD. This dismissal of RUQ pain as a symptom is unfortunate and means that the very real pain patients are experiencing is not taken seriously and that fatty liver disease that could have been caught earlier remains undetected.

    As doctors always like to remind us, the liver itself has no pain receptors. It has been hypothesized that RUQ pain associated with and near the liver may be caused by distension of Glisson’s capsule, which surrounds the liver and has many pain receptors.[ii] In other words, people who have an abnormally large liver due to inflammation, steatosis, or fibrosis may be putting pressure on the liver capsule, which manifests as pain in the RUQ. As you can see in the microscopic liver picture below, Glisson's capsule is partially highlighted in green, and is a thin layer around the liver.

    Though RUQ pain may be a sign of NAFLD or NASH, it may also be caused by other factors, so your doctor may only consider it a symptom if you are also experiencing unexplained fatigue or if you are a member of a population considered high-risk.[iii] That being said, it is one of the two more common symptoms that present in people with any stage of NAFLD/NASH. Even though NAFLD and NASH are mostly asymptomatic, RUQ pain could be a hint that you should consider thinking about your liver.

    Some patients who are able to lose weight and reduce steatosis in their liver may experience reductions in RUQ pain as they continue to decrease their stress on the liver. Other patients are successful at losing weight and still experience RUQ pain. On the flip side, people who have been temporarily successful at changing their diets and lifestyles may have reductions in RUQ pain that reemerge when they revert to their old habits. Know that everyone’s bodies react to changes in weight and diet differently, so don’t be discouraged if your RUQ pain doesn’t immediately disappear once you have made lifestyle changes. Remember that lifestyle changes are truly a commitment for life—not temporary or quick fixes.

    If you would like to read more about a patient's story involving RUQ pain, check out Terri's cautionary tale by clicking here.

     

    [i] cancertherapyadvisor.com/home/decision-support-in-medicine/gastroenterology-hepatology/nonalcoholic-steatohepatitis-and-nonalcoholic-fatty-liver-disease/

    [ii] cancertherapyadvisor.com/home/decision-support-in-medicine/gastroenterology-hepatology/nonalcoholic-steatohepatitis-and-nonalcoholic-fatty-liver-disease/

    [iii] https://www.healthgrades.com/right-care/liver-conditions/5-signs-and-symptoms-of-fatty-liver-disease

     


  • PPAR (say pee par) not a short putt, a potent liver disease drug

    PPAR -- Peroxisome proliferator-activated receptor

    Lanifibranor by Inventiva leads the way

    Wayne, you must be crazy to think I'll read something that starts out like that!!!

    Be calm, I promise, it will make sense and if liver disease interests you this will be worth your time.

    Therapies for NAFLD/NASH have been an elusive target and recent history is littered with promising molecules that many thought were finally going to lead to treatments for our disease. This is not a trivial problem. People are dying and our weapons are coffee and vitamin E.

    Don't get on me about lifestyle right now.  I know that tune but I also connect through our peer groups with thousands of people who need more than that and drugs will be part of a proper management of this disease if we can ever find something that works.

    Read more

  • MADRIGAL PRESENTS, Resmetirom a leader in NAFLD/NASH drug development

    Becky Taub and Paul Friedman, the founders of Madrigal Pharmaceuticals, are heroes of mine.

    Read more

  • One good TERN-101 deserves another, comments about a NASH clinical trial

    There has been a lot of disappointing news about NAFLD/NASH therapy research this past year.  I thought you might enjoy a look at some new data that is very encouraging. Terns Pharmaceutical just reported very positive 12 week results of the drug TERN-101. Below is a chart from their report about changes in results using a fairly new non-invasive test by Perspectum, the Liver MultiScan measuring a value called cT1 or corrected T1.  I'll explain it a bit later but for the moment just know that it is an indirect measure of fibrosis.  Click the image to see a larger view.  As a phase 2 study this is a small number of patients but the effect on their livers in only 12 weeks is among the best early data that we have seen.

    Read more

  • Leapfrog liver disease funding, a proposal for a better way

    We all know the issues. Too much disease, no treatments, a looming health crisis made worse by the pandemic. We are here on International NASH day and it seems like an apt time to wonder if there might be a better way.  If you haven't registered for the event I invite you to do so by clicking on the image below, but I also invite you to think about the future of research and how we as patients can support a better way.

    Read more

  • published Part 3: Patient Stories in Wellness Webinars 2021-05-06 09:14:08 -0600

    Part 3: Patient Stories

    CLICK HERE to view the recording of Wellness Webinar Part 3

    Welcome to Fatty Liver Foundation's Wellness Webinar Series. This six-part webinar series will deliver the latest research and medical information to people living with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and their medical providers. Our goal is to keep the patient community up-to-date on medical research and to build an archive of the important historical evolution of the field, while creating a space for patients to have their questions answered by top experts.

    FLF believes independent, clear, timely, and accurate information is vital for empowering patients to help them develop self-awareness, self-care, make informed decisions about participating in clinical trials, and promote understanding that patients can be equal partners in their healthcare decisions.

    Are you ready to join us for part-three of the FLF Wellness Webinar Series? This installment of the series will be brought to you by our Moderator Dr. Neeraj Mistry and a panel of patients who will be discussing the impact of COVID-19 on patients with liver disease. The session will be in a fireside chat format with the chance to answer your questions. This webinar will be limited to 100 registrants, sign up today to secure your spot!

    We look forward to your participation!

    Host: Wayne Eskridge, Co-Founder and CEO, Fatty Liver Foundation
    Moderator: Neeraj Mistry, MD, MPH, Chief Medical Officer, Fatty Liver Foundation
    Panelists: Terri Milton, Meagan Paullin, Tony Villiotti


  • ARGH not another webinar, too many I know but this may help you

    I remember Google before it became mostly an advertising farm.  To be able to get to information easily was magic. Today no matter where you go it is a parade of ads and cleverly designed hustles. Like search, now that video is so easy to do, the webinar world has exploded with ads. Since we don't sell anything and our only interest is having you not die of liver disease, getting past all the noise so that you might consider joining us is a real challenge.

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  • commented on Collagen, the last lesson, I promise, but this is important 2021-04-07 11:44:05 -0600
    Hello everyone! There have been several comments asking about dietary intake of collagen and its effect on NAFLD. To address the confusion about this old collagen series, I want to make it clear that the discussion around collagen was meant to inform you of the process of fibrosis formation, not to suggest that a dietary collagen supplement may be good or bad for NAFLD. Unfortunately, there is little to no data available about the effect of dietary collagen intake on NAFLD. Though collagen is a part of how scar tissue is formed, there is no research saying whether dietary collagen supplements have any effect on the rate of scar tissue formation in the liver. In terms of vitamin C, a 2016 study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732670/) showed that there may be a moderate inverse association between vitamin C intake and NAFLD, particularly for males and non-obese populations. Still, for both supplements, and many more, further research is needed. My best guess as to why scientists haven’t explored the topics more is that liver disease, and especially the step-children NAFLD and NASH, is generally under-investigated. As a Foundation, we are working to improve the awareness of NAFLD and NASH in the general public, which will ideally help drive increased research on these topics.
  • published Projects 2021-03-25 11:16:22 -0600

Executive Assistant & Program Coordinator @LiverSaver

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