Fatty Liver is Gone, Understanding the New Definition
Because of concern about stigma and the increasing knowledge about how fat in the liver leads to disease, the AASLD has officially adopted a new naming convention for our disease.
The new definition is under the umbrella term "STEATOTIC LIVER DISEASE", and what we know as NAFLD is now MASLD. NASH has been changed to MASH.
We are sponsoring a webinar for patients who want to understand the change this coming week. I encourage you to attend. This will change the way your physician talks to you about this disease. If you can't attend but would like to view it, we will distribute the recording to all registrants so go ahead and sign up.
CLICK THIS LINK TO REGISTER FOR THE WEBINAR
Read moreFALLS, do we care about "little" falls?
In my last blog I talked about my fall. When I fell I did quite a bit of damage and have 3 compression fractures to show for it. I've been surprised by the number of people who have commented about falling and most have had no problems and dismissed the event. Perhaps its time we took a closer look.
This is an MRI of my back after the fall.
Read moreAfter My Fall --- Old Folks and Old Cars Tend to Fall Apart All at Once
In my last blog I talked about falling and how bad that was for old folks. I mention that frequently in my communication with members of the foundation and I was disgusted that I tripped at night and had a hard fall.
Read moreDang Me, Dang Me, I broke another rule, but this is more serious
My hepatologist and every other doc always emphasized don't fall. I fell.
Last week, In the middle of a midnight bathroom run, I tripped and fell.
Not a terrible fall as nothing broken and no head impact but a big setback in my recovery from the back spasm. NASH patients tend to become riskier to falls as the disease progresses. That one of the reasons for keeping an exercise routine.
Read moreCan a patient beat NASH? Follow this blog, Sarah Larsen training for senior games.
Did you ever feel defeated by liver disease? Sarah Larsen decided to fight back. We are giving her a special blog space where she will document her training journey from patient to athlete training to compete in the World Senior Games.
Read moreHealth leaders who don't follow their own advice, I spit on thee
People who promote something, like politicians or health advocates, and then don't practice what they preach get my goat.
Read moreMadrigal files Resmetirom with FDA, possibly the first therapy for NASH
Madrigal Pharmaceuticals has released news that it has completed its filing for approval by FDA of its NASH drug candidate Resmetirom.
If you would like to read the official announcement, here is a link to it
Read moreAI, the next hinge point that will remake society, and you are a witness
There are hinge points in society which alter things in ways that fundamentally change how society works. The domestication of fire may have been the first. The development of projectile weapons and the efforts of the first farmers are examples. They can be large structural change like the development of the city/state or a knowledge engine like the invention of the printing press. They may be instantaneous like the explosion of the first atomic bomb or aspirational like the Magna Carta, but in all cases society changes as a result.
Read moreAI, what is it really and how will it affect patients
Join us for a webinar about AI and machine learning.
About a month ago, I shared some of my thoughts on the recent hysterics over AI. We know that panic and fear sells, so the media often plays on these emotions to garner more exposure and views. Unfortunately, these stories often fail to provide us with any meaningful information that might alleviate our concerns and instead leave us feeling more panicked and afraid than before we turned on the TV.
Read moreLiver patients may die at the feet of lawyers as potential therapy is denied
The makers of the first NASH drug that has met the goals set by FDA, Ocaliva by Intercept, have once again been told that if they spend another billion dollars they can apply again. Intercept is beaten and will withdraw.
Read moreMy Doctor Divorced Me!! Yours may do that to you soon too
My doctor divorced me. A new kind of care is being forced upon us.
It is an old story. They think we don't know, but we know. We get the little messages, "I wonder if we should see other people". We hear the office chatter, "Did you see the big ones that just came in"? "Sure a lot of newbies here lately." "There sure are a lot of young ones."
Read moreNASH-Day 2023 Conquering NASH is in sight, but the war is not won yet
We're here to mark a time in history when the Allied armies of science and medicine joined in battle to defeat the silent scourge of NAFLD/NASH. For decades, much of humanity has been under a terrible shadow. Countless faceless victims mourned only by their families have fallen to NASH, a disease of modern society. As the the medical world became aware of the killer stalking their patients the word went out from a few pioneers seeking answers. Even though the early researchers were largely ignored and the spotlight fell on the stars of heart and cancer they persevered.
Read moreFDA, a dance with the Red Queen in liver disease Wonderland
As I reported earlier, this was the outcome of the FDA meeting on the first drug candidate to successfully meet the FDA's requirement of reducing fibrosis by at least one stage.
The FDA advisory panel voted to reject Intercept's application for OCA as a treatment for NASH
Despite meeting the goals set by FDA, of reducing fibrosis by at least one stage, the GIDAC panel today voted against approval of obeticholic acid as a treatment for NASH.
Read moreFDA advisory panel votes against NAFLD/NASH therapy
The FDA advisory panel voted to reject Intercept's application for OCA as a treatment for NASH
Despite meeting the goals set by FDA, of reducing fibrosis by at least one stage, the GIDAC panel today voted against approval of obeticholic acid as a treatment for NASH.
As a patient, I'm very concerned by this decision. The concern expressed by the panel was that there was an increased risk of bile duct disease in a small number of patients in the clinical trial. The exact statistics will be published but we believe that the number is small compared to the number of people who will die from the disease if untreated Personally, I'd like to be able to have a chance to decide that risk for myself. I believe that most hepatologists know how to manage those risk factors.
Read moreFDA sausage being made tomorrow, will they kill another NASH drug
The FDA is finally going to act on the first drug for treatment of NASH
The FDA staff does not support approval - you can watch the meeting live if you care
Click this link to join the meeting 9:00 AM EST Friday May 19th
A little background. The Intercept drug obeticholic acid or OCA is the first drug to meet the FDA requirement of reducing NASH fibrosis by at least one stage. There is no therapy for NASH and it is a serious unmet need. We all know that and the meeting tomorrow will end with a vote of whether to recommend approval.
It is a public meeting and I invite you to watch. If you have NASH this could be significant for you. They have a brief window for public comment and I get 4 minutes to speak on our behalf as patients.
Read moreAI is coming!!! We are all going to die -- or maybe not -- clickbait anyone?
I am both amused and appalled by all of the stories about AI that are pummeling us lately. This is the latest fashion doing the walk down the breaking news parade route.
OK Wayne, just stop. You might know a little about liver disease but this is serious. I heard all the billionaires say its awful.
Maybe we could just take a breath. We need to remember that the world today runs on media exposure and audience. In the long ago we used to see cartoons about the guy in the public square with a sign saying "The World Is About To End". That was good for a chuckle. Today it's someone in a suit on TV with a new book or available for speaking tours. We have upgraded our doomsayers but now they are very successful at provoking our fear.
Read moreThe ICER man came, the ugly, the bad, and the good
IN BRIEF: ICER HATES obetacholic acid, and dislikes resmetirom
THE UGLY-- ICER voted 14 to 1 not to recommend obeticholic acid as a treatment for NASH
ICER voted 8 to 7 to reluctantly recommend resmetirom
A question that I found to be very distressing personally was defeated 9 to 6. The question: Would having a treatment for NASH have any effect on caregivers? Unbelievable
Read moreThe ICER man cometh, do you know how insurance denies you drugs?
New drugs are coming for liver disease, but will we be able to get them approved by insurance?
In a few weeks the FDA will have its public comment meeting for obetacholic acid for treatment of NASH. This is in response to an application by Intercept for approval. If FDA gives it a go ahead, the issue of the cost of the drug will be the next big thing.
Remember this, the insurance company is not actually in business for your health. They don't get bonuses because you were cured. Their job is to not spend all of the premium money so they carefully manage what they are willing to pay for.
Read moreHere at last! Here at last! The CARE SURVEY is here at last
With drugs coming soon, I REALLY NEED YOUR HELP!!!!!!
In the 2022 survey only about 10% of the patients contacted bothered to help. We need to do better. Here are links.
Read moreImportant information for NAFLD/NASH patients
The FDA will consider two drugs for treatment of NAFLD/NASH this year. I know we have been saying that therapy is coming for several years only to be disappointed. It is easy to be a little cynical about the prospects. This is a government agency and it seems like delay is what all agencies do best, but I do believe we will finally have a chance to move forward.
Read more