When we are diagnosed with F4 MASH (cirrhosis) we are often told that it is irreversible and the medical strategy is to just manage symptoms.  To be clear, there is a point of no return when a person is simply too ill to mount a defense, but before that the sense of hopelessness driven by the usual statement of "there is nothing we can do" is not useful.

I recently had a hernia repaired and, though it sounds odd, I welcomed the chance to get a look at my liver.  I had gallbladder surgery in 2010 and the doc took this picture which led to him telling my wife that I had cirrhosis and only a few years to live.

Patients facing the challenges of disease rarely consider how amazing they are physically.  There are many creatures that are stronger, faster, have better sight, hearing, or smell, for example.  The common view is that there is very little physically that we can point to and think of ourselves as special.  The mental gulf between us and other creatures is clear, but physically, the sense is that we are challenged. 

This is our annual survey of how patients with liver disease are doing.  I know you may have taken this survey before and we thank you, but if you have, it is important that you update this one.  Our goal is to track the changes in patient care over time.  The changes are important. How is treatment changing, are new therapies being prescribed, are patients being educated? These are just a few of the questions we are trying to answer.

This is the third in our series about fatty acids.  There is a lot of discussion about high fat/low fat diets and a tremendous amount of misinformation.  These articles are designed to help you understand how it all works so that you can make informed choices about the things you eat.

The body runs on a molecule called ATP, it is the energy carrier that all of your cells use to fuel their many functions. That ATP is produced by the mitochondria, which are tiny dynamos in all of your cells. You can't survive without a constant supply of ATP and it is made from either glucose or a fatty acid.  The body has two primary energy feedstocks, glucose or fats, and dietary fats are key sources of that energy.

Diet advocates routinely cast saturated fats as evil.  In the literature, you can find studies to support a wide variety of views of fats. You may recall when the USDA went all in on low fat and brought us things like margarine made with trans fats, which we know was a very bad idea.  We have prepared a research report about saturated fats to help you understand how they really fit with metabolism.  For the science minded a link to the full report is here. For those with a general interest, a summary is below in this blog.  The simplest message, as in all dietary discussions, the dose is key to understanding effects.

The Metabolism of Saturated Fatty Acids

The criticism of the western diet often focuses on seed oils and they are typically described as dangerous products which you should eliminate.  So many dietary debates focus on the extremes and the omega 6 issue is no exception. This blog will give you a broader perspective of the problem.

Look carefully at this chart.  You may think that liver disease is just for old people, but that would be wrong.  It is the 4th leading cause of death for the 45-54 age group.  That means that they were getting sick in their 30's.  Many of these people still have children at home. Since most of these diseases are preventable, that is truly a tragedy.  When I interact with people going through this, it breaks my heart.

It is unsettling when the political warfare that has gripped our country in recent years spills out of the halls of Washington threatening vast change.  As a patient community, we are concerned about what the changing times mean for us as many of the details can represent life and death for us.  The politicians and the other clickbait artists search for triggers that can generate a viral message, constantly driving our concerns.  I thought it might be useful to take a step back and consider where we stand today.

Akero just announced the results of its phase 2b Symmetry clinical trial of its FGF21 analog for F4 cirrhosis due to NASH/MASH and those results are just super.  There is a long way to go but we may be seeing the first real evidence of direct treatment for advanced fibrotic disease.

Coffee, should it be part of an effort to manage liver disease?

There is lots of talk about alternative therapy for what ails you since drugs are limited and expensive.  We all manage our day to day with only occasional contact with our docs and much depends on what we consume.

Passing milestones, like a year or a birthday, often lead one to reflect on life or the passage of time.  As I look back at my life, the metaphor that comes to mind is that of water.

The holidays are a difficult time for managing your diet.  Navigating the day to day challenge of what to eat is difficult for most of us, but it is easier if you understand how things work.  That gives you a way to evaluate the advice and the choices that you deal with when choosing what to eat.

A key premise of our approach to food is to try to minimize the amount of work the liver has to do.  It is capable of a vast array of chemical tasks, but when it is ill the best strategy is to be kind to it and to ask it to do as little work as possible.

Comparing Rezdiffra with Wegovy and Mounjaro In the context of NAFLD/NASH (MASLD/MASH)

Understanding how these very different drugs work in the context of steatotic liver disease

At the end of 2024 there are three drugs available for patients dealing with obesity and its consequences for liver disease.  Resmetirom marketed as Rezdiffra (Madrigal) is a liver specific drug and Semaglutide marketed as Wegovy (Novo Nordisk) and Tirzepatide marketed as Mounjaro by (Eli Lilly) are both focused on weight loss outside the liver. 

GLP-1 Weight Loss Drugs: A Guide to Novo Nordisk and Eli Lilly’s Innovations 

In the world of weight loss and diabetes management, GLP-1 receptor agonists have become a game-changer. These medications, originally developed for type 2 diabetes, are now widely used for effective weight loss. Two pharmaceutical giants, Novo Nordisk and Eli Lilly, have emerged as leaders in this space, offering groundbreaking drugs that redefine how obesity and metabolic disorders are treated. 

This guide explores the key aspects of GLP-1 drugs, focusing on the contributions of Novo Nordisk and Eli Lilly, their mechanisms of action, benefits, market trends, and the future of these transformative medications. 

The 2024 edition of our Care Survey is ready.  It gives a view of how patients experience liver disease over time, and how contact with medical care evolves.  We are beginning to see changes in patient care that are encouraging as the education efforts of patients and physicians begin to show results. I invite you to click on the image below and take a look at the report.

Madrigal recently released their 3rd quarter financial report.  They said they were very pleased and the invester community loved it pushing the Madrigal stock price up dramatically.  Take a look at this summary.

PPAR -- Peroxisome proliferator-activated receptor

Lanifibranor by Inventiva leads the way

Wayne, you must be crazy to think I'll read something that starts out like that!!!

Be calm, I promise, it will make sense and if liver disease interests you this will be worth your time.

The approval of the HistoSonics Edison system for liver cancer recently was surprisingly low key.  This is a quite remarkable advancement in the treatment of liver cancer.  HCC is one of the leading cancers and is increasing very rapidly in our liver community.

The Edison system liquifies tumors using focused ultrasound so no complicated internal therapies or surgeries.  To look at the company information use this link.

HistoSonics website

The promise of DNA guided care has been a long time coming but we are on the brink of practical application. I've had a keen interest in DNA so I decided to get my genome sequenced and to see what I could learn. I wanted to know if it could help me manage my health.

There are a few suppliers of sequencing and they fall into two types.  One version analyzes a catalog of short sequences called SNPS that have known interpretations and lend themselves to genealogy such as Ancestry and 23andME.  The other does a whole genome sequence and captures all of the DNA data which is a huge amount of information, much of which isn't really well understood yet, but it is research grade.

I haven't written about diet in some time and things have improved a bit for some people, but we have the next crop of victims of these crummy liver diseases on board so a little information from the real world might be of value.

First, there is no cleanse, superfood, magic pill, talisman, or faith healer that will fix your liver.  Beware of Dr Google as he might kill you after he takes your money. There are a few things that help some people marginally, but  generally they just service hope.